貼圖、程式等,版主可任意修改或刪除,轉貼文章請多用連結,一天 (00:00-23:59) 請只開一個話題,請大家合作,謝謝。05/25/2019 08:53:49     意見庫存
 

外獨會意見交流

 

如果失智是長壽的秘訣之一.....

發言人:油膩膩, on Apr/18/2019    16:24:34 (IP code: X.X.5.206)
 
那他們的生活模式,就很有參考價值。

就我觀察,失智症者的生活哲學有---不愛洗澡、不洗頭髮、不愛說話、不易生氣、聽不清楚、聞不太到、小口喝水、多坐少動。

 

Record ID: 1555575874   From: 台灣

回應貼文太多,中間略過,看全文請按這裡

回信 發言人:temo, on Apr/18/2019    19:21:44 (IP code: X.X.203.22)
 有生活哲學 不會是失智者. 你用錯辭, 找錯人了! 

Record ID: 1555575874R002   From: 台灣

回信 發言人:好酒不濺, on Apr/18/2019    19:28:13 (IP code: X.X.65.65)
 長者失智對照顧者還不算最可怕

最可怕的是緊接著失智而來的失能
包括大小便失禁挖糞塗牆等行為,對照顧者來講才是折磨!
 

Record ID: 1555575874R003   From: 台灣

回信 發言人:油膩膩, on Apr/18/2019    20:39:57 (IP code: X.X.5.206)
 R002


唉~~~~科技人,你就不能留心和品味<尊重、助人、感恩、包容、同理>嗎?


 

Record ID: 1555575874R004   From: 台灣

回信 發言人:BMIC, on Apr/18/2019    21:02:44 (IP code: X.X.83.131)
 油膩膩先生

您不到公園門口賣菜了?
 

Record ID: 1555575874R005   From: 美國

回信 發言人:BMIC, on Apr/18/2019    21:04:57 (IP code: X.X.83.131)
 今天談的又是牛頭不對馬嘴

您知道嗎??
 

Record ID: 1555575874R006   From: 美國

回信 發言人:BMIC, on Apr/18/2019    21:08:41 (IP code: X.X.83.131)
 大清早

美國東部五點, 我正在修改農業論文
上網, 看到了你這網路抄來的"勵志文章" (我不知道該用合話形容)

現在是九點
發覺沒人跟你更正你的鬼扯

我只好讓你不高興一下
 

Record ID: 1555575874R007   From: 美國

回信 發言人:BMIC, on Apr/18/2019    21:12:27 (IP code: X.X.83.131)
 你的開場白是對的, 因為你自己家中的老人家給您一個寶貴的經驗與觀察的機會

但是

R 001 就曝露你跟那一鍋支那獸醫的同一面

網路抄來牛頭不對馬嘴的文章

真是讓人對你有飢不擇食的感覺
 

Record ID: 1555575874R008   From: 美國

回信 發言人:BMIC, on Apr/18/2019    21:13:53 (IP code: X.X.83.131)
 >>>> 諾貝爾生理學獎得主伊麗莎白·布萊克本、卡蘿爾·格雷德和杰克·紹斯塔克等人,總結出幾把延緩人類衰老的長壽之道有五項--

尊重、助人、感恩、包容、同理。

==========================================================================
這是網路抄來的吧??
 

Record ID: 1555575874R009   From: 美國

回信 發言人:BMIC, on Apr/18/2019    21:22:03 (IP code: X.X.83.131)
 諾貝爾生理學獎得主伊麗莎白·布萊克本、卡蘿爾·格雷德和杰克·紹斯塔克等人,總結出幾把延緩人類衰老的長壽之道有五項--

尊重、助人、感恩、包容、同理。
===================================================================================

老實說

我努力地去找您說的相關文獻, 我怕我疏忽沒讀過...

Nobel Laureate Liz Blackburn 並沒有說過您上面抄來的鼕鼕

她的醫生和他的實驗結果, 讓人驚艷, 我曾讀了不少

就是沒有您抄來的這些網路半瓶子的結論

 

Record ID: 1555575874R010   From: 美國

回信 發言人:BMIC, on Apr/18/2019    21:25:10 (IP code: X.X.83.131)
 你曾談過的子玉米25 公分長, 我曾善意的案試提醒過您, 不要亂唬爛, 我對種田人還有一份感情, 誰知?

您都忘了??
 

Record ID: 1555575874R011   From: 美國

回信 發言人:BMIC, on Apr/18/2019    21:36:47 (IP code: X.X.83.131)
 >>>> 諾貝爾生理學獎得主伊麗莎白·布萊克本、卡蘿爾·格雷德和杰克·紹斯塔克等人

他們是研究老化的原因, 生命的長短是跟 telomere (端粒) 以及 telomerase 有關

This year’s Nobel Prize in Physiology or Medicine is awarded to three scientists who have solved a major problem in biology: how the chromosomes can be copied in a complete way during cell divisions and how they are protected against degradation. The Nobel Laureates have shown that the solution is to be found in the ends of the chromosomes – the telomeres – and in an enzyme that forms them – telomerase.

The long, thread-like DNA molecules that carry our genes are packed into chromosomes, the telomeres being the caps on their ends. Elizabeth Blackburn and Jack Szostak discovered that a unique DNA sequence in the telomeres protects the chromosomes from degradation. Carol Greider and Elizabeth Blackburn identified telomerase, the enzyme that makes telomere DNA. These discoveries explained how the ends of the chromosomes are protected by the telomeres and that they are built by telomerase.

If the telomeres are shortened, cells age. Conversely, if telomerase activity is high, telomere length is maintained, and cellular senescence is delayed. This is the case in cancer cells, which can be considered to have eternal life. Certain inherited diseases, in contrast, are characterized by a defective telomerase, resulting in damaged cells. The award of the Nobel Prize recognizes the discovery of a fundamental mechanism in the cell, a discovery that has stimulated the development of new therapeutic strategies.

The mysterious telomere
The chromosomes contain our genome in their DNA molecules. As early as the 1930s, Hermann Muller (Nobel Prize 1946) and Barbara McClintock (Nobel Prize 1983) had observed that the structures at the ends of the chromosomes, the so-called telomeres, seemed to prevent the chromosomes from attaching to each other. They suspected that the telomeres could have a protective role, but how they operate remained an enigma.

When scientists began to understand how genes are copied, in the 1950s, another problem presented itself. When a cell is about to divide, the DNA molecules, which contain the four bases that form the genetic code, are copied, base by base, by DNA polymerase enzymes. However, for one of the two DNA strands, a problem exists in that the very end of the strand cannot be copied. Therefore, the chromosomes should be shortened every time a cell divides – but in fact that is not usually the case (Fig 1).

Both these problems were solved when this year’s Nobel Laureates discovered how the telomere functions and found the enzyme that copies it.

Telomere DNA protects the chromosomes
In the early phase of her research career, Elizabeth Blackburn mapped DNA sequences. When studying the chromosomes of Tetrahymena, a unicellular ciliate organism, she identified a DNA sequence that was repeated several times at the ends of the chromosomes. The function of this sequence, CCCCAA, was unclear. At the same time, Jack Szostak had made the observation that a linear DNA molecule, a type of minichromosome, is rapidly degraded when introduced into yeast cells.

Blackburn presented her results at a conference in 1980. They caught Jack Szostak’s interest and he and Blackburn decided to perform an experiment that would cross the boundaries between very distant species (Fig 2). From the DNA of Tetrahymena, Blackburn isolated the CCCCAA sequence. Szostak coupled it to the minichromosomes and put them back into yeast cells. The results, which were published in 1982, were striking – the telomere DNA sequence protected the minichromosomes from degradation. As telomere DNA from one organism, Tetrahymena, protected chromosomes in an entirely different one, yeast, this demonstrated the existence of a previously unrecognized fundamental mechanism. Later on, it became evident that telomere DNA with its characteristic sequence is present in most plants and animals, from amoeba to man.

An enzyme that builds telomeres
Carol Greider, then a graduate student, and her supervisor Blackburn started to investigate if the formation of telomere DNA could be due to an unknown enzyme. On Christmas Day, 1984, Greider discovered signs of enzymatic activity in a cell extract. Greider and Blackburn named the enzyme telomerase, purified it, and showed that it consists of RNA as well as protein (Fig 3). The RNA component turned out to contain the CCCCAA sequence. It serves as the template when the telomere is built, while the protein component is required for the construction work, i.e. the enzymatic activity. Telomerase extends telomere DNA, providing a platform that enables DNA polymerases to copy the entire length of the chromosome without missing the very end portion.

Telomeres delay ageing of the cell
Scientists now began to investigate what roles the telomere might play in the cell. Szostak’s group identified yeast cells with mutations that led to a gradual shortening of the telomeres. Such cells grew poorly and eventually stopped dividing. Blackburn and her co-workers made mutations in the RNA of the telomerase and observed similar effects in Tetrahymena. In both cases, this led to premature cellular ageing – senescence. In contrast, functional telomeres instead prevent chromosomal damage and delay cellular senescence. Later on, Greider’s group showed that the senescence of human cells is also delayed by telomerase. Research in this area has been intense and it is now known that the DNA sequence in the telomere attracts proteins that form a protective cap around the fragile ends of the DNA strands.

An important piece in the puzzle – human ageing, cancer, and stem cells
These discoveries had a major impact within the scientific community. Many scientists speculated that telomere shortening could be the reason for ageing, not only in the individual cells but also in the organism as a whole. But the ageing process has turned out to be complex and it is now thought to depend on several different factors, the telomere being one of them. Research in this area remains intense.

Most normal cells do not divide frequently, therefore their chromosomes are not at risk of shortening and they do not require high telomerase activity. In contrast, cancer cells have the ability to divide infinitely and yet preserve their telomeres. How do they escape cellular senescence? One explanation became apparent with the finding that cancer cells often have increased telomerase activity. It was therefore proposed that cancer might be treated by eradicating telomerase. Several studies are underway in this area, including clinical trials evaluating vaccines directed against cells with elevated telomerase activity.

Some inherited diseases are now known to be caused by telomerase defects, including certain forms of congenital aplastic anemia, in which insufficient cell divisions in the stem cells of the bone marrow lead to severe anemia. Certain inherited diseases of the skin and the lungs are also caused by telomerase defects.

In conclusion, the discoveries by Blackburn, Greider and Szostak have added a new dimension to our understanding of the cell, shed light on disease mechanisms, and stimulated the development of potential new therapies.
 

Record ID: 1555575874R012   From: 美國

回信 發言人:BMIC, on Apr/18/2019    21:40:05 (IP code: X.X.83.131)
 諾貝爾生理學獎得主伊麗莎白·布萊克本、卡蘿爾·格雷德和杰克·紹斯塔克等人,總結出幾把延緩人類衰老的長壽之道有五項--

尊重、助人、感恩、包容、同理。

================================================================================
他們的研究結果並沒有說 "尊重、助人、感恩、包容、同理"可以增加telomerase 活性以及穩住telomere 的長度

他們沒有告訴你這些心理建設可以讓你更長壽

 

Record ID: 1555575874R013   From: 美國

回信 發言人:BMIC, on Apr/18/2019    21:42:46 (IP code: X.X.83.131)
 套上衣些世俗的話

人家沒有說的(你說的)應賽道人家嘴巴

就醬

(您先發一些時間去讀端粒和端粒酶, 之後有心獨再上來, 那是需要一些時間的)
 

Record ID: 1555575874R014   From: 美國

回信 發言人:BMIC更正, on Apr/18/2019    21:49:30 (IP code: X.X.83.131)
 套上一些世俗的話

人家沒有說的(你說的)你硬要塞到人家的嘴巴
 

Record ID: 1555575874R015   From: 美國

回信 發言人:BMIC更正, on Apr/18/2019    21:53:48 (IP code: X.X.83.131)
 老實說

我努力地去找您說的相關文獻, 我怕我疏忽沒讀過...

Nobel Laureate Liz Blackburn 並沒有說過您上面抄來的鼕鼕

她的一生和她的實驗結果, 真是讓人驚艷不已, 我曾讀了不少她的文章

但是, 就是沒有您抄來的這些網路半瓶子的結論
 

Record ID: 1555575874R016   From: 美國

回信 發言人:BMIC, on Apr/18/2019    23:29:06 (IP code: X.X.83.131)
 咦?

油膩膩早早上床?

明天大清早要去賣菜?

(對了, 您要以韓國瑜為效法對象, 您應該比他有才)
 

Record ID: 1555575874R017   From: 美國

回信 發言人:油膩膩, on Apr/19/2019    08:51:57 (IP code: X.X.5.206)
 R006~R016


嗯,是抄來的,少抄了很多。既然被你捉到了,就乖乖補上沒抄到的。

一、要樂觀!壓力會損傷身體
二、要有目標!「目標」能激發生命活力
三、助人為樂!「助人」有治療作用
四、家庭和睦!
五、友善!


著實是眼尖心細、追根究柢、精益求精的研究人!

 

Record ID: 1555575874R018   From: 台灣

回信 發言人:BMIC, on Apr/19/2019    09:09:55 (IP code: X.X.83.131)
 抄牛頭不對馬嘴的東西

真是連消化能力都沒有!

記住

那個諾貝爾獎得主沒有說過你抄來的勵志文章
 

Record ID: 1555575874R019   From: 美國

回信 發言人:BMIC, on Apr/19/2019    09:12:07 (IP code: X.X.83.131)
 >>>> 著實是眼尖心細、追根究柢、精益求精的研究人!

那是基本知識, 我一看就知道那是錯得離譜的串聯!!

可惜你不懂
 

Record ID: 1555575874R020   From: 美國

回信 發言人:BMIC, on Apr/19/2019    09:21:32 (IP code: X.X.83.131)
 以後要專貼網路文章

至少要曉得真偽
 

Record ID: 1555575874R021   From: 美國

本篇到此告一段落———版主

WE ARE 49ER TAIWANESE